Summary for peptidase M24.005: aminopeptidase P2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS Nameaminopeptidase P2
Other namesaminopeptidase P (eukaryote membrane-bound type), aminoacylproline aminopeptidase, membrane aminopeptidase P, microsomal proline aminopeptidase, X-Pro aminopeptidase (eukaryote), XPNPEP2 g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan MG >> Subclan (none) >> Family M24 >> Subfamily B >> M24.005
Holotypeaminopeptidase P2 (Sus scrofa), Uniprot accession Q95333 (peptidase unit: 351-602), MERNUM MER0002039
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00240
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.11 (Aminopeptidases) >> Peptidase 3.4.11.9
EnzymologyBRENDA database
Proteolytic eventsCutDB database (2 cleavages)
Activity statushuman: active (Simmons, 2004)
mouse: active (by similarity) (Ersahin et al., 2003)
PhysiologyProposed to have a role in degration of bradykinin and neuropeptide Y.
KnockoutA candidate gene for premature ovarian failure (Prueitt et al., 2000).
Pathways KEGGProtein digestion and absorption
Other databases TREEFAMhttp://www.treefam.org/family/TF314183
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/grScissile bondP/P/-/- (based on 13 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 3 0 0 3 0
Pro 0 0 0 0 13 10 0 1
Ala 0 0 0 0 0 0 0 0
Val 0 0 0 0 0 0 0 0
Leu 0 0 0 0 0 0 0 0
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 0 0 0 0 0
Phe 0 0 0 0 0 0 0 2
Tyr 0 0 0 1 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 0 1 0 0
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 0 0 0 0 0 0 0 0
Lys 0 0 0 0 0 0 1 0
Arg 0 0 0 3 0 0 0 0
His 0 0 0 0 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
XPNPEP2 Xq25 ENSG00000122121 7512 XPNPEP2 300145
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Xpnpep2 X:A3.2 ENSMUSG00000037005 170745 MGI:2180001