Summary for peptidase M24.007: Xaa-Pro dipeptidase (eukaryote)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma


MEROPS NameXaa-Pro dipeptidase (eukaryote)
Other namespeptidase D, PEPD g.p. (Homo sapiens), prolidase I, proline dipeptidase, peptidase 4 (Mus musculus), X-Pro dipeptidase
Domain architecture
MEROPS Classification
Classification Clan MG >> Subclan (none) >> Family M24 >> Subfamily B >> M24.007
HolotypeXaa-Pro dipeptidase (eukaryote) (Homo sapiens), Uniprot accession P12955 (peptidase unit: 225-477), MERNUM MER0001248
History Identifier created: MEROPS 3.03 (10 September 1998)
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00241
NC-IUBMBNot yet included in IUBMB recommendations.
Activity statushuman: active (Mock, 2004)
mouse: active (by similarity to rat) (Hu et al., 2003)
KnockoutProlidase deficiency is an autosomal recessive disorder with highly variable penetrance characterized by massive urinary excretion of imidodipeptides X-Pro and X-Hyp (Ledoux et al., 1996; Mandel et al., 2000). Prolidase deficiency is a risk factor for the development of systemic lupus erythematosus (Shrinath et al., 1997).
Pharmaceutical relevanceRecombinant prolidase is capable of destroying the organophosphorus toxin, soman (Wang et al., 2005).
Other databases TREEFAM
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PEPD 19cen-q13.11 ENSG00000124299 5184 PEPD 170100
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Pep4 7:A3 ENSMUSG00000001779 18624 MGI:97542