Summary for peptidase M24.009: aminopeptidase P1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Nameaminopeptidase P1
Other namesaminopeptidase P (eukaryote soluble type), XPNPEP1 g.p. (Homo sapiens), XPNPEPL g.p. (Homo sapiens), Xaa-Pro aminopeptidase 1 (Lycopersicon esculentum), Xaa-Pro aminopeptidase 2 (Lycopersicon esculentum), app1 g.p. (Lycopersicon esculentum), app2 g.p. (Lycopersicon esculentum)
Domain architecture
MEROPS Classification
Classification Clan MG >> Subclan (none) >> Family M24 >> Subfamily B >> M24.009
Holotypeaminopeptidase P1 (Homo sapiens), Uniprot accession Q9NQW7 (peptidase unit: 317-574), MERNUM MER0004321
History Identifier created: MEROPS 3.4 (5 November 1999)
Activity
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (3 cleavages)
Activity statushuman: active (Cottrell et al., 2000)
mouse: active (Czirjak et al. (1999))
Other databases TREEFAMhttp://www.treefam.org/family/TF314183
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/ryScissile bondP/-/pgk/- (based on 18 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 2 0 0 3 2
Pro 0 0 0 0 18 3 4 1
Ala 0 0 0 1 0 1 0 0
Val 0 0 0 0 0 1 0 0
Leu 0 0 0 0 0 1 0 0
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 0 0 0 0 0
Phe 0 0 0 2 0 3 0 2
Tyr 0 0 0 5 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 0 1 0 0
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 0 0 0 0 0 0 0 0
Lys 0 0 0 1 0 1 1 0
Arg 0 0 0 6 0 1 0 0
His 0 0 0 1 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
XPNPEP1 10q25.3 ENSG00000108039 7511 XPNPEP1 602443
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Xpnpep1 19:D2 ENSMUSG00000025027 170750 MGI:2180003