Summary for peptidase M24.026: aminopeptidase P3

Summary Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates

 

Names
MEROPS Nameaminopeptidase P3
Other namesICP55 peptidase, mitochondrial intermediate cleaving peptidase 55 kDa, X-prolyl aminopeptidase P3, XPNPEP3 g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan MG >> Subclan (none) >> Family M24 >> Subfamily B >> M24.026
Holotypeaminopeptidase P3 (Homo sapiens), Uniprot accession Q9NQH7 (peptidase unit: 242-501), MERNUM MER0013463
History Identifier created: MEROPS 5.3 (4 December 2000)
Activity
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
Activity statushuman: putative
mouse: putative
Other databases TREEFAMhttp://www.treefam.org/family/TF314484
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/YlfScissile bondSat/st/-/sak (based on 39 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 0 1 4 2
Pro 0 0 0 0 1 0 3 4
Ala 0 0 0 0 9 1 7 7
Val 0 0 0 0 0 1 3 4
Leu 0 0 0 9 0 2 5 1
Ile 0 0 0 0 0 0 2 1
Met 0 0 0 0 0 0 0 0
Phe 0 0 0 5 0 0 0 0
Tyr 0 0 0 25 1 0 1 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 25 11 2 8
Thr 0 0 0 0 3 10 1 2
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 3 5 0
Gln 0 0 0 0 0 3 1 0
Asp 0 0 0 0 0 3 1 1
Glu 0 0 0 0 0 2 1 0
Lys 0 0 0 0 0 0 2 7
Arg 0 0 0 0 0 0 0 0
His 0 0 0 0 0 2 1 2
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
XPNPEP3 22q13.31-q13.33 ENSG00000100382 63929