Summary for peptidase M26.001: IgA1-specific metallopeptidase

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors


MEROPS NameIgA1-specific metallopeptidase
Other namesimmunoglobulin A1 proteinase, IgA protease (Streptococcus sp.)
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(E) >> Family M26 >> Subfamily (none) >> M26.001
HolotypeIgA1-specific metallopeptidase (Streptococcus sanguinis), Uniprot accession Q59986 (peptidase unit: 530-1878), MERNUM MER0001173
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00242
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase
EnzymologyBRENDA database
ActivityThe enzyme from {Streptococcus pneumoniae} has been expressed in active form (<%Romanello %etal, 2005[20050921A060]%>).
Proteolytic eventsCutDB database (1 cleavage)
SpecificitySpecific for cleavage of the hinge region of IgA1.
PhysiologyInactivation of host IgA1 in immune avoidance possible.