Summary for peptidase M28.001: aminopeptidase Y

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors

 

Names
MEROPS Nameaminopeptidase Y
Other namesaminopeptidase Co, APE3 g.p. (Saccharomyces cerevisiae), APY1, cobalt-activated aminopeptidase, Lap2 g.p. (Aspergillus fumigatus), Lap2 g.p. (Trichophyton rubrum), lysyl aminopeptidase (yeast)
Domain architecture
MEROPS Classification
Classification Clan MH >> Subclan (none) >> Family M28 >> Subfamily A >> M28.001
Holotypeaminopeptidase Y (Saccharomyces cerevisiae), Uniprot accession P37302 (peptidase unit: 273-509), MERNUM MER0001288
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00245
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.11 (Aminopeptidases) >> Peptidase 3.4.11.15
EnzymologyBRENDA database
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bond-/-/-/- (based on 28 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 0 0 0 0
Pro 0 0 0 2 0 0 0 0
Ala 0 0 0 3 1 0 0 0
Val 0 0 0 0 0 0 0 0
Leu 0 0 0 3 0 0 0 0
Ile 0 0 0 0 0 0 0 0
Met 0 0 0 3 0 0 0 0
Phe 0 0 0 2 0 0 0 0
Tyr 0 0 0 1 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 3 0 0 0 0
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 1 0 0 0 0
Asn 0 0 0 2 0 0 0 0
Gln 0 0 0 2 0 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 0 0 0 0 0 0 0 0
Lys 0 0 0 2 0 0 0 0
Arg 0 0 0 2 1 0 0 0
His 0 0 0 0 0 0 0 0