Summary for peptidase M28.002: aminopeptidase Ap1

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

 

Names
MEROPS Nameaminopeptidase Ap1
Other namesAeromonas aminopeptidase
Domain architecture
MEROPS Classification
Classification Clan MH >> Subclan (none) >> Family M28 >> Subfamily E >> M28.002
Holotypeaminopeptidase Ap1 (Vibrio proteolyticus), Uniprot accession Q01693 (peptidase unit: 148-401), MERNUM MER0001284
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00246
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.11 (Aminopeptidases) >> Peptidase 3.4.11.10
EnzymologyBRENDA database
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bond-/-/-/- (based on 66 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 3 4 5 5 4
Pro 0 0 0 0 0 1 2 1
Ala 0 0 0 0 1 1 4 4
Val 0 0 0 5 5 2 1 2
Leu 0 0 0 14 5 4 5 6
Ile 0 0 0 1 1 0 0 1
Met 0 0 0 6 5 4 3 2
Phe 0 0 0 8 6 5 4 2
Tyr 0 0 0 1 2 0 1 1
Trp 0 0 0 3 3 1 1 1
Ser 0 0 0 5 5 5 2 3
Thr 0 0 0 4 5 6 5 4
Cys 0 0 0 0 1 1 1 1
Asn 0 0 0 2 2 2 1 1
Gln 0 0 0 4 4 4 2 1
Asp 0 0 0 0 2 2 2 2
Glu 0 0 0 0 3 4 5 4
Lys 0 0 0 4 2 1 1 1
Arg 0 0 0 2 4 3 2 3
His 0 0 0 3 3 3 3 3