Summary for peptidase M35.004: peptidyl-Lys metallopeptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namepeptidyl-Lys metallopeptidase
Other namesAm-LysN, GfMep (Grifola), metalloendopeptidase Lys-N, PoMep (Pleurotus sp.)
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(D) >> Family M35 >> Subfamily (none) >> M35.004
Holotypepeptidyl-Lys metallopeptidase (Armillaria mellea), Uniprot accession Q9Y7F7 (peptidase unit: 184-351), MERNUM MER0005595
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00252
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.20
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
PhysiologyRole in nutrition of organism.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/-Scissile bondK/-/-/- (based on 2105 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 123 135 140 175 0 116 166 141
Pro 117 107 84 86 0 87 72 101
Ala 154 154 149 159 0 159 158 149
Val 117 131 118 108 0 125 126 167
Leu 179 192 229 223 0 163 238 188
Ile 120 116 121 101 0 105 147 143
Met 60 73 82 73 0 85 55 54
Phe 54 46 78 60 0 60 92 74
Tyr 56 50 56 52 0 69 53 80
Trp 19 20 28 26 0 13 16 20
Ser 149 147 162 159 0 150 145 149
Thr 114 124 123 92 0 126 124 117
Cys 34 18 34 39 0 30 27 30
Asn 78 91 82 101 0 89 87 74
Gln 85 85 85 105 0 92 97 96
Asp 139 137 93 114 0 132 112 107
Glu 214 209 162 204 0 214 145 173
Lys 131 111 127 108 2105 112 126 105
Arg 102 112 112 94 0 128 82 99
His 56 44 39 26 0 48 35 36