Summary for peptidase M38.001: isoaspartyl dipeptidase (metallo-type)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors


MEROPS Nameisoaspartyl dipeptidase (metallo-type)
Other namesbeta-aspartyl dipeptidase, iadA g.p. (Escherichia coli)
Domain architecture
MEROPS Classification
Classification Clan MJ >> Subclan (none) >> Family M38 >> Subfamily (none) >> M38.001
Holotypeisoaspartyl dipeptidase (metallo-type) (Escherichia coli), Uniprot accession P39377 (peptidase unit: 10-359), MERNUM MER0001495
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00441
NC-IUBMBNot yet included in IUBMB recommendations.
ActivityIsoaspartyl dipeptidase hydrolyses a variety of isoaspartyl amino acids, as reviewed by <%Gary & Clarke (2004)[20040525A429]%>.
InhibitorsIsoaspartyl dipeptidase is inhibited by the phosphinate Asp-Psi[PO(2)CH(2)]-LeuOH (Jozic et al., 2003).
PhysiologyPrevents accumulation of isoaspartyl peptides, thought to be toxic to bacteria.