Summary for peptidase M41.001: FtsH peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS NameFtsH peptidase
Other namesHflB protease, filamentation temperature sensitive H peptidase, MrsC g.p. (Escherichia coli), tolZ g.p. (Escherichia coli)
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(E) >> Family M41 >> Subfamily (none) >> M41.001
HolotypeFtsH peptidase (Escherichia coli), Uniprot accession P0AAI3 (peptidase unit: 365-647), MERNUM MER0001620
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00253
NC-IUBMBNot yet included in IUBMB recommendations.
PhysiologyProposed role in proteolytic quality control of regulatory molecules and membrane proteins, in yeast.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/lScissile bond-/-/-/- (based on 24 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 1 0 0 0 1 1 1
Pro 2 1 1 0 1 0 2 3
Ala 3 3 3 2 2 1 1 1
Val 1 1 2 1 1 3 2 3
Leu 5 3 6 8 4 5 3 5
Ile 1 2 0 1 0 1 1 1
Met 1 1 1 1 1 0 1 0
Phe 2 2 1 1 2 0 1 0
Tyr 0 0 0 1 1 1 1 2
Trp 1 0 1 1 1 1 1 1
Ser 2 3 2 1 5 1 2 2
Thr 1 1 3 0 0 1 1 0
Cys 0 0 0 0 0 0 0 0
Asn 1 1 0 0 1 0 0 0
Gln 2 2 3 1 1 2 4 2
Asp 0 1 0 0 0 0 0 0
Glu 0 2 1 3 1 4 3 3
Lys 0 0 0 2 2 2 0 0
Arg 1 0 0 1 1 0 0 0
His 0 0 0 0 0 1 0 0