Summary for peptidase M41.018: AtFtsH11 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature


MEROPS NameAtFtsH11 peptidase
Other namesFTSH11 g.p. (Arabidopsis thaliana)
Name and HistoryIn plants, FtsH peptidases are directed to the mitochondrion or the chloroplast. There are twelve homologues in Arabidopsis thaliana and nine in Oryza sativa (Zhang & Sun, 2009). FtsH peptidases have been shown to degrade unassembled thylakoid membrane proteins and photodamaged photosystem II D1 protein in response to stress induced by strong light.
Domain architecture
MEROPS Classification
Classification Clan MA >> Subclan MA(E) >> Family M41 >> Subfamily (none) >> M41.018
HolotypeAtFtsH11 peptidase (Arabidopsis thaliana), Uniprot accession Q9FGM0 (peptidase unit: 568-806), MERNUM MER0014324
History Identifier created: MEROPS 7.60 (23 October 2006)
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
PreparationThe peptidase has never been purified and all experiments have been genetic manipulations.
SpecificityA membrane-bound, ATP-dependent endopeptidase (Urantowka et al., 2005).
LocationFound in both chloroplasts and mitochondria. In the mitochondrion, AtFtsH11 is integral to the inner membrane with its catalytic site exposed towards the intermembrane space (Urantowka et al., 2005).
PhysiologyAtFtsH11 occurs in at least two complexes with molecular masses in excess of 1500 kDa (Urantowka et al., 2005). AtFtsH11 plays a role in temperature stress, because plants bearing mutant forms show reduced photosynthesis when exposed to moderately high temperatures (30 degrees C) (Chen et al., 2006).
Distinguishing featuresOf the four FtsH homologues in Arabidopsis, only AtFtsH4 and AtFtsH11 face the mitochondrial intermembrane space whereas AtFtsH3 and AtFtsH10 face the matrix (Urantowka et al., 2005). AtFtsH is also found in the chloroplast.
Contributing authorsNeil D. Rawlings, Bateman Group, Wellcome Trust Sanger Institute and EMBL European Bioinformatics Institute, Hinxton, Cambridgeshire, CB10 1SA, UK