|Peplist||Included in the Peplist with identifier PL00257|
|NC-IUBMB||Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 18.104.22.168|
|Proteolytic events||CutDB database (3 cleavages)|
|Activity status||human: active (Oxvig et al., 2004)|
mouse: active (by similarity to human) (Conover et al., 2004)
|Physiology||Pappalysin-1 cleaves insulin-like growth factor (IGF) binding protein-4 (IGFBP-4), causing a dramatic reduction in its affinity for IGF-I and -II. Acting in this way it is a regulator of IGF bioactivity in the human ovary and the cardiovascular system (Laursen et al., 2002). Pappalysin-1 is also responsible for IGF-dependent degradation of IGFBP-2 (Monget et al., 2003). Also contributes to the physiological proteolysis of IGFBP-5 (Rivera & Fortune, 2003). There is evidence that pappalysin-1 plays an essential role in determining IGF-II bioavailability for optimal fetal growth and development in the mouse (Bale & Conover, 2005).|
|Knockout||Mice homozygous for targeted disruption of the pappalysin-1 gene were viable but 60% the size of wild-type littermates at birth (Conover et al., 2004).