Summary for peptidase M50.001: site 2 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates


MEROPS Namesite 2 peptidase
Other namesmembrane-bound transcription factor protease site 2, MBTPS2 g.p. (Homo sapiens), S2P protease, site-2 protease, sterol regulatory element-binding protein site 2 protease, SREBP S2 protease, S2P peptidase
Domain architecture
MEROPS Classification
Classification Clan MM >> Subclan (none) >> Family M50 >> Subfamily A >> M50.001
Holotypesite 2 peptidase (Homo sapiens), Uniprot accession O43462 (peptidase unit: 1-519), MERNUM MER0004458
History Identifier created: MEROPS 3.03 (10 September 1998)
Catalytic typeMetallo
PeplistIncluded in the Peplist with identifier PL00260
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase
EnzymologyBRENDA database
Proteolytic eventsCutDB database (3 cleavages)
Activity statushuman: active (Rawson, 2004)
mouse: active (by similarity to human) (Duncan et al., 1998)
Other databases TREEFAM
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MBTPS2 X ENSG00000012174 51360 MBTPS2 300294
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Mbtps2 X:F4 ENSMUSG00000046873 270669 MGI:2444506