Summary for peptidase M79.002: RCE1 peptidase (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors Pharma

 

Names
MEROPS NameRCE1 peptidase (Homo sapiens-type)
Other namesAtFACE-2 (Arabidopsis thaliana), Face-2 protein (Homo sapiens), Ras converting CAAX endopeptidase 1, RCE1 g.p. (Homo sapiens), prenyl peptidase 1, prenyl protease 1
Domain architecture
MEROPS Classification
Classification Clan (unassigned) >> Subclan (none) >> Family M79 >> Subfamily (none) >> M79.002
HolotypeRCE1 peptidase (Homo sapiens-type), Uniprot accession Q9Y256 (peptidase unit: 33-312), MERNUM MER0004246
History Identifier created: MEROPS 9.3 (7 September 2010)
Activity
Catalytic typeMetallo
NC-IUBMBNot yet included in IUBMB recommendations.
Pathways KEGGTerpenoid backbone biosynthesis
Other databases TREEFAMhttp://www.treefam.org/family/TF313800
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternK/T/K/-Scissile bondVl/I/ML/- (based on 22 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 1 0 0 0 0 0
Pro 0 0 0 0 0 0 0 0
Ala 0 0 0 0 0 0 0 0
Val 0 0 0 0 11 1 0 0
Leu 0 0 0 0 4 1 6 0
Ile 1 0 0 0 1 17 0 0
Met 0 0 0 0 0 2 9 0
Phe 0 0 0 0 1 0 0 0
Tyr 0 0 0 0 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 1 0 0 0 0 1 0
Thr 0 12 0 0 0 0 0 0
Cys 0 0 0 2 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 0 0 0 0 0 0 0 0
Lys 13 1 13 0 0 0 0 0
Arg 0 0 0 0 0 0 0 0
His 0 0 0 0 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
RCE1 11q13 ENSG00000173653 9986 RCE1B 605385
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Rce1 19:A ENSMUSG00000024889 19671 MGI:1336895