Summary for peptidase M9E.004: membrane Pro-Xaa carboxypeptidase

Summary Distribution Literature Substrates

 

Names
MEROPS Namemembrane Pro-Xaa carboxypeptidase
Other namescarboxypeptidase P, microsomal prolyl carboxypeptidase
MEROPS Classification
Classification Clan (unassigned) >> Subclan (unassigned) >> Family (unassigned) >> Subfamily (unassigned) >> M9E.004
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.17 (Metallocarboxypeptidases) >> Peptidase 3.4.17.16
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
PhysiologyProbable role in final stage of hydrolysis of proline-containing peptides.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/PagScissile bondfa/-/-/- (based on 20 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 2 2 1 0 0 0
Pro 0 2 0 13 0 0 0 0
Ala 1 1 2 5 4 0 0 0
Val 1 1 0 0 0 0 0 0
Leu 0 0 0 0 0 0 0 0
Ile 0 1 0 0 1 0 0 0
Met 0 0 0 0 3 0 0 0
Phe 0 0 0 0 6 0 0 0
Tyr 1 0 0 0 2 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 0 0 0 0 0 0 0
Thr 0 0 0 0 1 0 0 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 0 0
Gln 0 0 0 0 0 0 0 0
Asp 0 0 1 0 0 0 0 0
Glu 0 0 0 0 0 0 0 0
Lys 0 0 0 0 0 0 0 0
Arg 0 0 0 0 2 0 0 0
His 0 0 1 0 0 0 0 0