Summary for peptidase M9G.026: dactylysin

Summary Distribution Literature Substrates

 

Names
MEROPS Namedactylysin
Other namesPHIE, peptide hormone inactivating endopeptidase, peptide-hormone inactivating enzyme (Xenopus)
MEROPS Classification
Classification Clan (unassigned) >> Subclan (unassigned) >> Family (unassigned) >> Subfamily (unassigned) >> M9G.026
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeMetallo
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.24 (Metalloendopeptidases) >> Peptidase 3.4.24.60
EnzymologyBRENDA database
Proteolytic eventsCutDB database (3 cleavages)
PhysiologyHydrolyses bioactive amphipathic peptides.
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/gv/gfhScissile bondFlh/mr/-/- (based on 23 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 3 3 8 7 0 1 0 0
Pro 0 1 1 1 0 0 2 0
Ala 4 4 1 0 0 2 0 1
Val 0 3 5 0 1 0 0 2
Leu 0 1 0 1 6 3 2 0
Ile 1 0 0 0 2 0 0 1
Met 0 0 0 0 0 5 3 1
Phe 0 4 1 6 10 3 1 2
Tyr 3 1 0 1 0 0 1 0
Trp 3 0 0 0 0 1 0 0
Ser 1 0 1 2 0 1 0 0
Thr 0 1 1 0 0 0 0 1
Cys 1 1 0 0 0 0 0 0
Asn 0 0 2 0 0 0 0 0
Gln 1 2 1 0 1 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 1 0 0 0 0 0 0 0
Lys 2 1 1 1 0 1 2 0
Arg 1 1 0 0 0 5 1 0
His 1 0 1 4 3 1 0 0