Summary for peptidase S01.010: granzyme B (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Substrates Inhibitors Pharma

 

Names
MEROPS Namegranzyme B (Homo sapiens-type)
Other namesGZMB g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.010
Holotypegranzyme B (Homo sapiens-type), Uniprot accession P10144 (peptidase unit: 21-247), MERNUM MER0000168
History Identifier created: MEROPS 3.1 (22 December 1998)
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00265
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (315 cleavages)
Pharmaceutical relevanceIt has been reported that a low blood level of granzyme B is a potential marker of influenza risk in older adults (McElhaney et al., 2001). Auto-antibodies directed against granzyme B-generated peptides have been recognised in scleroderma and ischemic digital loss (Schachna et al., 2002).
Pathways KEGGAllograft rejection
KEGGAutoimmune thyroid disease
KEGGGraft-versus-host disease
KEGGNatural killer cell mediated cytotoxicity
KEGGTranscriptional misregulation in cancer
KEGGType I diabetes mellitus
Other databases TREEFAMhttp://www.treefam.org/family/TF333630
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternvi/-/-/DScissile bond-/-/-/- (based on 1873 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 38 225 204 6 100 208 75 100
Pro 136 8 277 2 5 11 64 58
Ala 111 158 249 11 291 188 122 140
Val 459 83 150 3 124 68 200 156
Leu 252 108 110 20 113 298 152 147
Ile 345 41 25 1 42 85 128 98
Met 99 50 31 19 39 55 38 53
Phe 72 24 49 5 64 77 53 51
Tyr 27 13 14 4 48 74 63 26
Trp 9 4 6 6 3 8 7 8
Ser 46 213 148 23 374 159 154 124
Thr 56 86 110 7 150 68 106 94
Cys 13 36 16 5 21 13 12 9
Asn 29 66 71 49 71 31 53 54
Gln 29 88 132 10 69 66 54 73
Asp 26 183 48 1398 94 165 133 230
Glu 67 349 176 261 166 211 281 342
Lys 36 60 38 19 62 57 149 78
Arg 7 36 9 22 19 17 14 13
His 10 41 10 2 16 12 10 14
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
GZMB 14q11.2 ENSG00000100453 3002 GZMB 123910