Summary for peptidase S01.033: factor VII-activating peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS Namefactor VII-activating peptidase
Other namesfactor VII-activating protease, FSAP, HABP2 g.p. (Homo sapiens), hyaluronan-binding peptidase, hyaluronan-binding protease, hyaluronic acid-binding protease, PHBP, plasma hyaluronan-binding protein, plasma hyaluronan-binding serine protease, single-chain plasminogen activator-activating protease
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.033
Holotypefactor VII-activating peptidase (Homo sapiens), Uniprot accession Q14520 (peptidase unit: 314-557), MERNUM MER0003612
History Identifier created: MEROPS 5.0 (17 April 2000)
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00267
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Etscheid, 2004)
mouse: active (by similarity to human) (Hashimoto et al., 1997)
PhysiologyThe Marburg I polymorphism of hyaluronan-binding peptidase (G511E) is associated with risk of cardiovascular disease (Ireland et al., 2004). This polymorphism attenuates the capacity of the enzyme to activate prourokinase (Willeit et al., 2003).
Other databases TREEFAMhttp://www.treefam.org/family/TF329901
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/RScissile bonds/-/-/- (based on 11 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 1 1 0 0 0 3 3
Pro 1 1 1 0 1 1 0 0
Ala 1 0 0 0 0 0 1 0
Val 0 0 0 0 0 2 0 0
Leu 1 0 0 0 0 1 0 1
Ile 0 1 0 0 2 0 0 1
Met 0 1 0 0 0 0 0 0
Phe 0 0 2 0 0 0 1 2
Tyr 0 0 0 0 0 1 1 0
Trp 0 0 0 0 0 0 0 0
Ser 1 0 1 0 3 2 0 0
Thr 0 1 0 0 0 1 0 1
Cys 1 0 0 0 0 0 0 0
Asn 0 1 0 0 0 0 1 0
Gln 0 1 2 0 1 0 0 0
Asp 0 0 0 0 0 0 0 1
Glu 1 0 0 0 0 0 1 0
Lys 1 2 3 2 2 1 1 0
Arg 1 0 1 9 1 0 1 1
His 1 1 0 0 0 1 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
HABP2 10q25.3 ENSG00000148702 3026 603924
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Habp2 19:D2 ENSMUSG00000025075 226243 MGI:1196378