Summary for peptidase S01.047: human airway trypsin-like peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Human EST Substrates Inhibitors

 

Names
MEROPS Namehuman airway trypsin-like peptidase
Other namesadrenal secretory serine protease, airway trypsin-like protease, HAT peptidase, TMPRSS11D g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.047
Holotypehuman airway trypsin-like peptidase (Rattus norvegicus), Uniprot accession Q8VHJ4 (peptidase unit: 186-417), MERNUM MER0011864
History Identifier created: MEROPS 5.2 (31 August 2000)
Activity
Catalytic typeSerine
NC-IUBMBNot yet included in IUBMB recommendations.
Activity statushuman: active (Yasuoka et al., 1997)
mouse: putative
PhysiologyAn endopeptidase with restricted specificity known from both rat adrenal gland and human airways.
Pathways KEGGInfluenza A
Other databases TREEFAMhttp://www.treefam.org/family/TF351684
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/RScissile bond-/-/-/- (based on 95 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 6 6 9 0 16 5 10 8
Pro 4 5 11 0 0 4 4 6
Ala 10 7 12 1 10 11 9 10
Val 0 6 6 0 8 10 5 10
Leu 7 6 8 1 9 12 10 11
Ile 6 5 2 0 3 5 1 9
Met 2 2 2 0 1 2 1 2
Phe 1 6 0 0 0 1 3 1
Tyr 2 2 3 0 0 2 3 2
Trp 1 0 0 0 1 0 0 0
Ser 7 6 5 0 9 5 8 6
Thr 5 5 9 1 4 4 6 6
Cys 0 3 1 0 1 2 1 0
Asn 2 2 5 0 0 5 4 5
Gln 2 3 3 0 1 11 7 2
Asp 1 0 2 0 0 0 1 6
Glu 0 1 0 0 0 0 0 0
Lys 3 9 3 1 15 8 15 7
Arg 9 5 2 91 7 4 0 0
His 1 0 2 0 7 1 4 1
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
TMPRSS11D 4q13.2 ENSG00000153802 9407 605369