Summary for peptidase S01.133: cathepsin G

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namecathepsin G
Other namesCatG, CTSG g.p. (Homo sapiens), Stat5 protease
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.133
Holotypecathepsin G (Homo sapiens), Uniprot accession P08311 (peptidase unit: 21-245), MERNUM MER0000082
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00271
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.20
EnzymologyBRENDA database
Proteolytic eventsCutDB database (31 cleavages)
Activity statushuman: active (Salvesen, 2004)
mouse: active (MacIvor et al., 1999)
PhysiologyCathepsin G is bactericidal, and contributes to the digestion of bacteria by polymorphonuclear leukocytes. It has been suggested that neutrophils auto-regulate their lytic efficiency by controlling the exocytosis of primary granules via cathepsin G activity (Ottonello et al., 2004). Cathepsin G has also been known as "STAT5 protease" because of its activity in processing signal transducer and activator of transcription (STAT) proteins (Schuster et al., 2007).
KnockoutCathepsin G-deficient mice had no distinctive phenotype (MacIvor et al., 1999), but the enzyme seemed to contribute to the intracellular killing of fungi in neutrophil leukocytes, and to sensitivity to endotoxic shock (Tkalcevic et al., 2000).
Pathways KEGGAmoebiasis
KEGGLysosome
KEGGNeuroactive ligand-receptor interaction
KEGGRenin-angiotensin system
KEGGSystemic lupus erythematosus
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Cathepsin_G
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/v/-/lhfScissile bonds/-/-/v (based on 464 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 34 34 13 2 36 33 52 40
Pro 35 6 45 0 2 4 35 19
Ala 18 34 36 6 50 24 120 43
Val 25 120 30 15 38 31 22 128
Leu 13 27 105 107 29 34 13 21
Ile 21 20 32 14 21 13 16 21
Met 17 3 10 31 9 6 6 4
Phe 12 12 6 94 11 18 23 10
Tyr 9 5 4 47 4 11 8 5
Trp 1 4 2 1 5 91 6 1
Ser 12 22 27 0 138 30 17 23
Thr 7 17 45 4 17 24 22 11
Cys 5 7 1 0 3 1 2 8
Asn 8 14 15 16 23 23 13 18
Gln 21 22 24 3 18 9 15 9
Asp 95 22 12 5 6 46 29 17
Glu 24 48 37 2 5 37 21 46
Lys 0 2 5 3 19 1 12 20
Arg 12 6 3 3 7 3 9 2
His 20 8 5 105 14 15 9 4
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CTSG 14q11.2 ENSG00000100448 1511 CTSG 116830
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Ctsg 14:C1 ENSMUSG00000040314 13035 MGI:88563