Summary for peptidase S01.134: myeloblastin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namemyeloblastin
Other namesAGP7, c-ANCA, neutrophil leukocyte proteinase 3, neutrophil leukocyte proteinase 4, p29b, PR3, proteinase 3, PRTN3 g.p. (Homo sapiens), Wegener’s granulomatosis autoantigen
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.134
Holotypemyeloblastin (Homo sapiens), Uniprot accession P24158 (peptidase unit: 28-250), MERNUM MER0000170
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00272
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.76
EnzymologyBRENDA database
Proteolytic eventsCutDB database (18 cleavages)
Activity statushuman: active (Rao & Hoidal, 2004)
mouse: active (Jenne et al., 1997)
PhysiologyProbable role in killing and digestion of bacteria by leukocytes. Involvement in growth and differentiation of human leukemic cells.
Pharmaceutical relevanceThe antigen against which the autoimmunity of Wegener"s granulomatosis is directed. A major target of autoimmune reactions triggered by hepatitis C virus infection (Wu et al., 2002).
Other databases TREEFAMhttp://www.treefam.org/family/TF335284
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/y/y/vtaScissile bond-/-/-/- (based on 52 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 4 0 3 0 2 4 4 2
Pro 0 0 6 2 0 1 1 6
Ala 4 4 0 6 0 2 1 2
Val 2 4 1 12 5 1 1 3
Leu 6 4 5 1 3 6 3 3
Ile 1 1 0 0 1 2 3 4
Met 0 0 1 0 1 0 1 0
Phe 4 2 3 1 3 3 2 2
Tyr 5 15 13 0 0 1 2 3
Trp 0 0 0 0 0 1 0 1
Ser 5 5 2 2 7 3 5 1
Thr 3 4 5 8 5 3 1 2
Cys 0 0 1 3 0 0 0 1
Asn 0 1 2 0 1 1 3 0
Gln 0 0 1 0 0 3 3 0
Asp 0 0 2 1 1 5 1 2
Glu 0 1 5 0 3 2 3 2
Lys 3 3 0 4 0 1 2 1
Arg 1 3 0 1 3 4 1 2
His 0 3 1 0 2 2 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PRTN3 19p13.3 ENSG00000172229 5657 PRTN3 177020
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Prtn3 10:C1 ENSMUSG00000020125 19152 MGI:893580