Summary for peptidase S01.135: granzyme A

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Pharma

 

Names
MEROPS Namegranzyme A
Other namesCTLA3, GZMA g.p. (Homo sapiens), HuTSP, T-cell associated protease 1, T-cell specific proteinase 1, TSP-1
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.135
Holotypegranzyme A (Homo sapiens), Uniprot accession P12544 (peptidase unit: 29-261), MERNUM MER0001379
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00273
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.78
EnzymologyBRENDA database
Proteolytic eventsCutDB database (8 cleavages)
Activity statushuman: active (Froelich, 2004)
mouse: active (Odake et al., 1991)
KnockoutGranzyme A-deficient mice retain potent cell-mediated cytotoxicity (Ebnet et al., 1995).
Pathways KEGGNeuroactive ligand-receptor interaction
Other databases TREEFAMhttp://www.treefam.org/family/TF333630
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/RKScissile bonda/gl/-/- (based on 441 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 28 46 19 5 29 99 59 33
Pro 44 4 67 4 0 2 17 11
Ala 57 58 30 11 134 60 36 49
Val 39 40 15 4 22 11 15 35
Leu 39 13 51 13 9 88 40 51
Ile 47 19 4 0 11 20 26 35
Met 8 16 6 0 4 17 7 3
Phe 3 3 19 2 1 11 23 4
Tyr 5 15 33 2 8 6 2 12
Trp 1 0 4 0 0 0 0 0
Ser 20 65 64 0 59 27 43 19
Thr 38 20 28 15 36 10 17 14
Cys 2 4 10 1 3 3 2 2
Asn 5 10 15 0 12 4 10 18
Gln 5 23 7 0 18 26 33 24
Asp 7 26 27 1 12 11 14 14
Glu 21 32 12 1 10 33 32 45
Lys 21 25 11 129 52 7 53 57
Arg 35 18 13 253 0 0 2 0
His 8 2 4 0 17 0 4 8
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
GZMA 5q11-q12 ENSG00000145649 3001 GZMA 140050
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Gzma 13:D ENSMUSG00000023132 14938 MGI:109266