Summary for peptidase S01.139: granzyme M

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS Namegranzyme M
Other namesGZMM g.p. (Homo sapiens), met-ase
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.139
Holotypegranzyme M (Rattus norvegicus), Uniprot accession Q03238 (peptidase unit: 21-252), MERNUM MER0000155
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00274
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (4 cleavages)
Activity statushuman: active (Smyth, 2004)
mouse: active (Kelly et al., 1996)
Other databases TREEFAMhttp://www.treefam.org/family/TF335738
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternk/-/p/LScissile bond-/-/-/- (based on 1363 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 35 38 152 13 49 106 91 108
Pro 113 11 309 6 2 5 97 78
Ala 127 145 227 62 212 296 146 159
Val 60 114 75 7 65 91 77 66
Leu 119 86 92 741 45 134 70 65
Ile 53 40 22 17 51 46 40 49
Met 52 33 33 180 33 31 24 22
Phe 18 34 17 25 15 79 17 20
Tyr 14 40 25 6 20 79 25 11
Trp 6 3 2 0 1 0 4 0
Ser 37 118 68 45 244 148 130 135
Thr 27 68 48 54 89 57 56 62
Cys 9 17 10 32 42 7 11 9
Asn 14 54 15 42 79 43 30 50
Gln 123 106 52 44 59 34 69 63
Asp 6 72 17 3 49 36 137 113
Glu 25 251 85 12 63 36 175 158
Lys 412 69 84 41 207 92 127 126
Arg 72 49 23 28 13 10 12 23
His 39 15 7 4 10 18 10 31
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
GZMM 19p13.3 ENSG00000099805 3004 GZMM 600311
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Lmet1 10:C ENSMUSG00000020125 16904 MGI:99549