Summary for peptidase S01.141: mast cell peptidase 1 (Rattus-type)

Summary Gene structure Alignment Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namemast cell peptidase 1 (Rattus-type)
Other namesrat mast cell protease 2, rMCP-2, chymase 2 (Rattus norvegicus)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.141
Holotypemast cell peptidase 1 (Rattus-type) (Rattus norvegicus), Uniprot accession P00770 (peptidase unit: 21-246), MERNUM MER0000126
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00276
NC-IUBMBNot yet included in IUBMB recommendations.
KnockoutIn mice, disruption of the gene led to profound histochemical and ultrastructural changes in intestinal mucosal mast cell granules (Wastling et al., 1998).
Pharmaceutical relevanceChymase inhibitors showed promise for the prevention of post-operative adhesions in a hamster model (Okamoto et al., 2004; Soga et al., 2004). Also, a chymase inhibitor prevented the development of abdominal aortic aneurysm in a hamster experimental model (Tsunemi et al., 2004).
Other databases TREEFAMhttp://www.treefam.org/family/TF333630