Summary for peptidase S01.143: tryptase alpha

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Substrates Inhibitors Pharma

 

Names
MEROPS Nametryptase alpha
Other namestryptase alpha 1 (Homo sapiens), TPSAB1 g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.143
Holotypetryptase alpha (Homo sapiens), Uniprot accession P15157 (peptidase unit: 31-274), MERNUM MER0000135
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00278
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.59
EnzymologyBRENDA database
Proteolytic eventsCutDB database (11 cleavages)
PhysiologyHas potential to cleave a variety of extracellular proteins of biomedical importance.
Pharmaceutical relevanceRegarded as a drug target for asthma and antigen-induced bronchoconstriction (Slusarchyk et al., 2002; Sutton et al., 2002).
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/KRScissile bond-/-/-/- (based on 23 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 2 2 0 1 0 3 2
Pro 3 0 3 0 0 1 2 1
Ala 2 1 0 0 2 0 1 1
Val 0 1 2 0 1 0 0 1
Leu 2 3 2 0 0 3 2 1
Ile 0 1 0 0 1 1 1 0
Met 1 0 0 0 0 1 1 0
Phe 1 2 1 0 0 1 0 1
Tyr 0 1 0 0 2 1 0 0
Trp 0 0 0 0 0 0 0 0
Ser 2 0 2 0 2 0 1 1
Thr 1 0 0 0 0 0 0 2
Cys 0 0 0 0 0 0 0 0
Asn 0 1 1 0 1 0 2 1
Gln 0 2 0 0 1 3 0 0
Asp 1 1 4 0 1 2 0 1
Glu 0 0 1 0 0 1 2 1
Lys 1 2 1 13 3 0 0 0
Arg 3 2 1 10 0 1 0 1
His 0 1 0 0 0 0 0 1
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
TPSAB1 16p13.3 ENSG00000172236 7176 TPS1 191080