Summary for peptidase S01.146: granzyme K

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Substrates Pharma

 

Names
MEROPS Namegranzyme K
Other namesgranzyme 3, NK tryptase 2, RNK-Tryp-2, tryptase TL2, GZMK g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.146
Holotypegranzyme K (Homo sapiens), Uniprot accession P49863 (peptidase unit: 27-261), MERNUM MER0001936
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00279
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (4 cleavages)
Activity statushuman: active (Babe & Schmidt, 2004)
mouse: active (Wilharm et al., 1999)
Other databases TREEFAMhttp://www.treefam.org/family/TF333630
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/py/RkScissile bond-/l/-/v (based on 20 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 2 1 1 0 1 0 1 1
Pro 0 0 5 0 0 0 1 2
Ala 0 0 0 0 5 2 1 0
Val 1 3 0 0 0 2 0 5
Leu 1 2 0 0 1 5 3 0
Ile 0 0 0 0 0 2 0 0
Met 2 0 0 0 1 0 3 0
Phe 1 0 2 0 0 1 0 0
Tyr 3 1 4 0 2 0 0 0
Trp 1 0 1 0 0 0 0 0
Ser 0 1 0 0 2 0 1 0
Thr 0 1 1 0 0 1 1 1
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 1 0
Gln 3 4 1 0 1 1 0 0
Asp 2 2 0 0 1 0 1 2
Glu 1 0 2 0 0 0 1 1
Lys 1 1 1 4 2 1 0 1
Arg 0 1 0 16 1 0 1 0
His 0 1 0 0 1 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
GZMK 5q11-q12 ENSG00000113088 3003 GZMK 600784
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Gzmk 13:D2.2 ENSMUSG00000042385 14945 MGI:1298232