Summary for peptidase S01.150: mast cell peptidase 5 (mouse numbering)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namemast cell peptidase 5 (mouse numbering)
Other namesmast cell protease 5 (mouse numbering), mMCP-5, rMCP-5, chymase 5 (Mus musculus), chymase 2 (Mesocricetus auratus), hamster chymase 2, mast cell protease 2 (Meriones unguiculatus), mast cell protease 5 (Rattus norvegicus)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.150
Holotypemast cell peptidase 5 (mouse numbering) (Mus musculus), Uniprot accession P21844 (peptidase unit: 22-247), MERNUM MER0000121
History Identifier created: MEROPS 3.02 (25 June 1998)
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00280
NC-IUBMBNot yet included in IUBMB recommendations.
KnockoutMice null for mast cell peptidase 5 (mMCP-5) showed reduction of muscle injury due to ischemia with subsequent reperfusion (IR) injury, leading the authors to propose a cytotoxic activity of this mast cell-specific peptidase, and to conclude that mMCP-5 is critical for irreversible IR injury of skeletal muscle (Abonia et al., 2005).
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patterng/lv/lv/ViapScissile bond-/eld/-/h (based on 44 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 9 0 1 0 0 1 1 3
Pro 8 1 3 3 0 0 0 0
Ala 3 3 4 4 3 0 2 3
Val 7 11 12 27 4 0 7 6
Leu 2 14 13 0 3 11 4 6
Ile 0 0 0 8 4 2 1 3
Met 1 2 2 0 3 1 1 0
Phe 2 0 0 2 1 0 3 1
Tyr 0 0 1 0 1 1 0 0
Trp 0 0 0 0 2 0 1 2
Ser 0 1 0 0 7 1 6 2
Thr 2 4 5 0 4 1 2 1
Cys 1 0 0 0 0 1 0 0
Asn 0 0 0 0 3 0 0 0
Gln 1 1 2 0 2 1 1 0
Asp 0 0 0 0 0 6 0 0
Glu 1 5 0 0 2 15 0 0
Lys 2 0 1 0 0 0 3 0
Arg 2 2 0 0 5 0 4 4
His 0 0 0 0 0 0 5 10
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Mcpt5 14:C1 ENSMUSG00000022225 17228 MGI:96941