Summary for peptidase S01.152: chymotrypsin B

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namechymotrypsin B
Other nameschymotrypsin (Homo sapiens-type), chymotrypsin 2 (Canis familiaris), CTRB1 g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.152
Holotypechymotrypsin B (Bos taurus), Uniprot accession P00767 (peptidase unit: 16-245), MERNUM MER0000004
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00282
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Graf et al., 2004)
mouse: active (by similarity) (Honey et al., 1984)
PhysiologyRole in intestinal digestion of food proteins in mammals.
Pathways KEGGPancreatic secretion
KEGGProtein digestion and absorption
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Chymotrypsin_B
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patterna/a/pv/fylwScissile bond-/-/-/dv (based on 26 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 1 0 0 2 0 0 0
Pro 1 1 7 0 0 0 1 1
Ala 5 8 0 0 1 1 0 0
Val 0 0 4 0 0 0 0 3
Leu 0 1 2 6 0 2 3 0
Ile 1 0 0 0 0 0 0 0
Met 0 1 0 1 0 1 0 1
Phe 1 0 0 8 0 0 0 0
Tyr 1 0 1 7 0 0 1 0
Trp 0 0 0 3 0 0 0 0
Ser 1 0 0 0 2 0 0 0
Thr 2 1 2 0 0 2 2 2
Cys 0 1 0 0 1 0 0 0
Asn 0 0 0 1 2 0 1 0
Gln 0 0 1 0 0 1 1 0
Asp 0 1 2 0 2 1 0 3
Glu 0 0 0 0 0 1 0 0
Lys 2 2 1 0 0 1 2 1
Arg 0 2 0 0 1 0 0 0
His 1 0 1 0 0 1 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CTRB1 16q23.2-q23.3 ENSG00000168925 1504 CTRB1 118890
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Ctrb1 8:E1 ENSMUSG00000031957 66473 MGI:1913723