Summary for peptidase S01.153: elastase-1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Nameelastase-1
Other namesCELA1 g.p. (Homo sapiens), CELA g.p. (Mus musculus), CELA g.p. (Rattur norwegicus), pancreatopeptidase E, pancreatic elastase, p6-5 protein, PRT-201, vonapanitase
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.153
Holotypeelastase-1 (Sus scrofa), Uniprot accession P00772 (peptidase unit: 27-266), MERNUM MER0000142
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00283
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.36
EnzymologyBRENDA database
Proteolytic eventsCutDB database (15 cleavages)
Activity statushuman: active (Bieth, 2004)
mouse: active (by similarity) (Honey et al., 1984)
PhysiologyRole in intestinal digestion of food proteins in mammals.
Pharmaceutical relevanceEvaluated as drug target for acute pancreatitis.
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Elastase
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patterna/-/-/avScissile bond-/-/-/- (based on 51 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 3 3 4 2 2 3 1 0
Pro 3 0 10 0 0 1 3 1
Ala 10 7 6 15 3 3 2 1
Val 3 4 3 11 4 2 4 1
Leu 5 3 4 6 4 6 3 4
Ile 3 0 1 3 0 0 1 0
Met 1 1 1 0 1 0 1 2
Phe 0 1 4 0 3 3 0 0
Tyr 1 2 1 3 2 3 3 1
Trp 0 0 0 0 0 0 0 0
Ser 2 5 1 4 5 1 4 6
Thr 0 3 0 4 2 1 1 3
Cys 2 3 2 1 1 2 2 3
Asn 2 1 0 0 1 2 0 1
Gln 1 1 1 1 1 3 2 0
Asp 0 0 0 0 0 0 1 0
Glu 2 5 2 0 3 2 4 7
Lys 0 0 2 0 1 0 1 0
Arg 0 1 2 0 0 1 0 2
His 0 3 2 1 1 0 1 1
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CELA1 12q13 ENSG00000139610 1990 ELA1 130120
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Ela1 15 ENSMUSG00000023031 13704 MGI:95314