Summary for peptidase S01.155: pancreatic elastase II

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namepancreatic elastase II
Other nameselastase 2A, elastase C (Gadus morhua), CELA2A g.p. (Homo sapiens), CELA2B g.p. (Homo sapiens), chymotrypsin-like elastase family, member 2A, ELA2A g.p. (Homo sapiens), pancreatic elastase 2, pancreatic elastase IIA (Homo sapiens), rat mesenteric arterial bed elastase-2
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.155
Holotypepancreatic elastase II (Sus scrofa), Uniprot accession P08419 (peptidase unit: 29-269), MERNUM MER0000144
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00285
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.71
EnzymologyBRENDA database
Activity statushuman: active (Bieth, 2004)
mouse: active (by similarity)
Pharmaceutical relevanceEvaluated as drug target for acute pancreatitis.
Pathways KEGGPancreatic secretion
KEGGProtein digestion and absorption
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Pancreatic_elastase
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CELA2A 1p36.21 ENSG00000142615 63036 609443
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Ela2 10 ENSMUSG00000028918 13706 MGI:95316