Summary for peptidase S01.156: enteropeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Substrates Inhibitors

 

Names
MEROPS Nameenteropeptidase
Other namesenterokinase, PRSS7 g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.156
Holotypeenteropeptidase (Bos taurus), Uniprot accession P98072 (peptidase unit: 801-1035), MERNUM MER0000207
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00286
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.9
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Sadler, 2004)
mouse: active (Yuan et al., 1998)
BiotechnologyReagent for cleavage of recombinant fusion proteins.
InhibitorsNot trapped by alpha-2-macroglobulin (Barrett 1981).
PhysiologyActivates trypsinogen and other pancreatic proenzymes in intestine.
KnockoutHuman enteropeptidase deficiency is a rare hereditary condition first described in 1969 (Mann & Mann, 1994).
Pharmaceutical relevancePossible role in acute pancreatitis.
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Enteropeptidase
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternds/dg/Dey/RKScissile bond-/glv/G/gs (based on 21 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 4 0 0 1 5 14 8
Pro 0 0 0 0 0 0 0 1
Ala 1 0 1 0 3 2 1 0
Val 2 1 0 0 0 4 1 0
Leu 0 1 0 0 0 4 0 0
Ile 0 0 0 0 3 0 0 0
Met 0 0 0 0 5 2 0 0
Phe 0 0 0 0 1 0 0 0
Tyr 0 1 3 0 0 0 0 0
Trp 1 0 0 0 2 1 0 1
Ser 6 2 1 0 1 0 1 7
Thr 0 0 0 0 0 0 0 0
Cys 0 0 0 0 2 0 2 0
Asn 0 2 0 0 0 0 0 0
Gln 1 0 0 0 1 0 1 1
Asp 6 8 11 0 0 0 0 1
Glu 1 2 5 0 0 0 0 1
Lys 0 0 0 7 0 1 0 0
Arg 1 0 0 14 1 1 0 0
His 1 0 0 0 0 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
TMPRSS15 21q21 ENSG00000154646 5651 PRSS7 226200
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Prss7 16:C3.1 ENSMUSG00000022857 19146 MGI:1197523