Summary for peptidase S01.157: chymotrypsin C

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Pharma

 

Names
MEROPS Namechymotrypsin C
Other namescaldecrin, CTRC g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.157
Holotypechymotrypsin C (Bos taurus), Uniprot accession Q7M3E1 (peptidase unit: 30-268), MERNUM MER0002738
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00287
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.2
EnzymologyBRENDA database
Proteolytic eventsCutDB database (2 cleavages)
Activity statushuman: active (Szilagyi, 2004)
mouse: active (by similarity to rat) (Tomomura et al., 1995)
PhysiologyRuminant digestive enzyme. Reported to be factor that depresses plasma calcium in acute pancreatitis.
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Chymotrypsin-C
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/lfqyScissile bond-/-/-/- (based on 36 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 2 2 1 0 2 2 2 2
Pro 0 0 4 0 0 1 2 1
Ala 4 4 2 0 0 0 2 1
Val 3 4 3 0 3 1 2 0
Leu 2 3 3 12 4 5 1 4
Ile 2 0 1 0 0 0 0 0
Met 0 0 0 1 1 1 1 0
Phe 2 2 2 7 1 1 1 0
Tyr 1 2 3 6 4 1 3 3
Trp 0 1 1 1 1 0 1 0
Ser 2 5 3 0 2 3 2 1
Thr 1 0 1 0 2 3 2 2
Cys 1 1 0 0 0 1 0 0
Asn 2 0 2 1 3 3 4 2
Gln 4 3 2 7 1 2 0 2
Asp 1 0 2 0 4 3 3 2
Glu 2 3 2 0 2 2 1 3
Lys 0 1 1 0 0 1 1 1
Arg 2 2 0 0 0 0 1 2
His 0 1 2 0 1 0 0 1
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CTRC 1p36.21 ENSG00000162438 11330 CTRC 601405
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Ctrc 4:E1 ENSMUSG00000062478 76701 MGI:1923951