Summary for peptidase S01.159: prostasin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma


MEROPS Nameprostasin
Other namesCAP1, channel-activating protease-1, PRSS8 g.p. (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.159
Holotypeprostasin (Homo sapiens), Uniprot accession Q16651 (peptidase unit: 45-288), MERNUM MER0002460
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00288
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Chao, 2004)
mouse: active (Vuagniaux et al., 2000)
PhysiologyAn endopeptidase known from epithelial cells of Xenopus and mouse that can activate the amiloride-sensitive sodium channel (ENaC) in mammalian kidney epithelial cells, and may act as a regulator of ENaC within the kidney (Vuagniaux et al., 2000).
KnockoutProstasin expression in the epidermis is crucial for the epidermal permeability barrier and indispensable for postnatal survival (Leyvraz, et al. 2005).
Other databases TREEFAM
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PRSS8 16p11.2 ENSG00000052344 5652 PRSS8 600823
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Prss8 7:F3 ENSMUSG00000030800 76560 MGI:1923810