Summary for peptidase S01.160: kallikrein 1

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Substrates Inhibitors Pharma

 

Names
MEROPS Namekallikrein 1
Other namesglandular kallikrein, kallikrein hK1 (Homo sapiens), kidney kallikrein, pancreatic kallikrein, KLK1 g.p. (Homo sapiens), submandibular kallikrein, submaxillary kallikrein, urinary kallikrein, kallikrein 1 (Homo sapiens)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.160
Holotypekallikrein 1 (Sus scrofa) (peptidase unit: 25-262), MERNUM MER0000092
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00289
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.35
EnzymologyBRENDA database
Proteolytic eventsCutDB database (4 cleavages)
InhibitorsNot trapped by alpha-2-macroglobulin (Barrett 1981).
PhysiologyProcesses kininogen to release hypotensive kinin peptides including kallidin.
Pharmaceutical relevanceIt is reported that vascular kinin-mediated symptoms of experimental oedematous pancreatitis in the rat are caused by the action of tissue kallikrein (Griesbacher et al., 2002).
Pathways KEGGEndocrine and other factor-regulated calcium reabsorption
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/KLK1
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/fl/RyScissile bondSr/-/g/- (based on 31 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 1 1 0 0 0 0 7 2
Pro 1 3 1 0 0 0 2 2
Ala 4 7 2 0 1 3 0 5
Val 0 2 0 0 0 0 2 0
Leu 3 0 7 0 1 0 1 2
Ile 3 0 0 1 1 2 0 1
Met 0 0 0 1 0 2 0 0
Phe 0 1 8 2 0 1 1 1
Tyr 0 0 1 8 1 1 1 1
Trp 0 0 1 2 0 0 0 0
Ser 4 4 3 0 13 2 2 2
Thr 2 3 1 0 0 4 1 2
Cys 1 1 0 0 0 0 0 0
Asn 1 1 0 0 1 1 0 1
Gln 1 0 1 0 0 1 1 2
Asp 0 2 0 0 0 0 0 0
Glu 4 1 1 0 0 0 0 0
Lys 0 1 1 2 1 2 3 0
Arg 0 2 1 15 6 6 3 3
His 0 0 1 0 0 0 1 1