Summary for peptidase S01.161: kallikrein-related peptidase 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Substrates Inhibitors Pharma

 

Names
MEROPS Namekallikrein-related peptidase 2
Other nameskallikrein 2, kallikrein hk2 (Homo sapiens), KLK2 g.p. (Homo sapiens), human glandular kallikrein 1 [obs.], hGK1
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.161
Holotypekallikrein-related peptidase 2 (Homo sapiens), Uniprot accession P20151 (peptidase unit: 25-260), MERNUM MER0000094
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00290
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (28 cleavages)
BiotechnologyPossible use as diagnostic in detection of prostate cancer has been proposed (Finlay et al., 2001).
Pathways KEGGEndocrine and other factor-regulated calcium reabsorption
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/KLK2
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patterng/-/-/RScissile bond-/-/-/gst (based on 66 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 25 10 6 0 3 8 17 21
Pro 4 3 3 0 1 8 4 1
Ala 3 2 4 0 5 7 1 1
Val 3 2 4 0 3 4 3 1
Leu 1 3 7 1 7 4 1 4
Ile 5 1 0 0 8 7 1 2
Met 0 2 1 0 6 1 1 0
Phe 1 1 8 0 1 1 0 0
Tyr 0 0 1 1 2 0 3 1
Trp 0 0 0 0 0 2 0 1
Ser 3 7 9 0 15 5 9 11
Thr 5 8 7 0 3 3 2 10
Cys 1 0 0 0 0 0 0 2
Asn 1 0 1 0 1 3 4 1
Gln 1 7 4 0 2 1 3 1
Asp 0 2 1 0 2 1 3 0
Glu 7 4 1 0 0 2 3 2
Lys 1 4 2 6 2 1 2 2
Arg 0 5 5 57 2 1 3 1
His 1 4 2 1 0 4 3 1
Specificity from combinatorial peptides
 
Organism comment P4 P3 P2 P1 P1' P2' P3' P4' optimal substrate fluorophore or acceptor-donor pair Reference
Homo sapiens recombinant K A H R - - - - KAHR+xxxx Abz-Tyr(NO2) Janssen et al., 2004
Homo sapiens recombinant A F R R - - - - GKAFRR AMC Janssen et al., 2004
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
KLK2 19q13.2-q13.4 ENSG00000167751 3817 KLK2 147960