Summary for peptidase S01.162: kallikrein-related peptidase 3

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Substrates Inhibitors Pharma

 

Names
MEROPS Namekallikrein-related peptidase 3
Other namesAPS g.p. [obs.] (Homo sapiens), hk3, kallikrein 3, kallikrein hK3, P-30 antigen, prostate-specific antigen, PSA, seminin, gamma-seminoprotein, KLK3 g.p. (Homo sapiens), semenogelase
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.162
Holotypekallikrein-related peptidase 3 (Homo sapiens), Uniprot accession P07288 (peptidase unit: 25-260), MERNUM MER0000115
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00291
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.77
EnzymologyBRENDA database
Proteolytic eventsCutDB database (37 cleavages)
BiotechnologyUsed in detection and assessment of prostate cancer.
Pharmaceutical relevanceA potential drug target for prostatic and other cancers (Gygi et al., 2002).
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/KLK3
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternsi/sq/-/yqrScissile bonds/s/-/- (based on 83 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 5 2 0 0 4 7 6 10
Pro 1 3 4 0 0 1 3 5
Ala 5 3 1 0 4 0 0 3
Val 4 2 6 0 4 10 3 3
Leu 1 5 10 4 5 4 2 2
Ile 13 4 4 0 7 6 1 1
Met 1 0 0 2 1 0 1 0
Phe 0 0 5 2 1 0 0 0
Tyr 0 0 10 32 1 2 0 2
Trp 0 0 1 0 0 0 1 0
Ser 25 21 9 0 19 17 9 4
Thr 0 2 6 0 5 1 5 6
Cys 0 3 0 2 0 0 0 1
Asn 2 0 2 2 3 4 12 1
Gln 6 20 12 19 3 5 7 3
Asp 0 2 0 2 2 2 1 4
Glu 1 1 0 1 1 3 5 8
Lys 0 8 3 2 1 3 5 4
Arg 7 4 1 9 3 1 1 1
His 1 2 8 6 2 1 4 4
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
KLK3 19q13.3-q13.4 ENSG00000142515 354 KLK3 176820