Summary for peptidase S01.172: kallikrein 1-related peptidase c2 (Rattus norvegicus)

Summary Gene structure Alignment Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

 

Names
MEROPS Namekallikrein 1-related peptidase c2 (Rattus norvegicus)
Other nameskallikrein klk1c2 (Rattus sp.), kallikrein rk2 (Rattus sp.), tonin
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.172
Holotypekallikrein 1-related peptidase c2 (Rattus norvegicus), Uniprot accession P00759 (peptidase unit: 25-258), MERNUM MER0000107
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00294
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (1 cleavage)
PhysiologyLiberates angiotensin II directly from precursors.
Pathways KEGGEndocrine and other factor-regulated calcium reabsorption
Other databases TREEFAMhttp://www.treefam.org/family/TF331065
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/p/RfyScissile bondhg/L/l/- (based on 21 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 2 2 0 3 1 2 2
Pro 1 1 5 0 0 0 0 0
Ala 1 0 0 1 0 0 0 1
Val 3 3 0 0 0 0 1 1
Leu 2 0 0 0 1 7 4 0
Ile 4 0 0 0 0 0 0 1
Met 0 0 0 0 0 0 1 1
Phe 1 1 3 5 1 1 1 0
Tyr 1 0 0 2 0 1 0 2
Trp 0 0 0 0 1 1 0 0
Ser 0 1 1 0 1 0 0 1
Thr 0 0 1 0 0 0 0 0
Cys 1 0 0 0 1 0 2 0
Asn 0 1 1 0 0 0 0 2
Gln 1 2 1 1 0 0 0 0
Asp 0 0 0 0 0 0 0 0
Glu 0 0 2 0 0 1 0 0
Lys 0 1 1 0 0 0 0 0
Arg 0 1 0 12 0 0 0 0
His 0 3 0 0 4 0 0 0