Summary for peptidase S01.191: complement factor D

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors

 

Names
MEROPS Namecomplement factor D
Other namesadipsin, C3 proactivator convertase, PoDAK peptidase (Paralichthys olivaceus)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.191
Holotypecomplement factor D (Homo sapiens), Uniprot accession P00746 (peptidase unit: 26-253), MERNUM MER0000130
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00299
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.46
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Volanakis, 2004)
mouse: active (Xu et al., 2001)
PhysiologyHydrolyses factor B in suitable complexes, leading to complement factor C3 cleavage.
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Complement_factor_D
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CFD 19 ENSG00000177649 1675 DF 134350
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Adn 10:C1 ENSMUSG00000020125 11537 MGI:87931