Summary for peptidase S01.192: complement component activated C1r

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namecomplement component activated C1r
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.192
Holotypecomplement component activated C1r (Homo sapiens), Uniprot accession P00736 (peptidase unit: 478-716), MERNUM MER0000238
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00300
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.41
EnzymologyBRENDA database
Proteolytic eventsCutDB database (4 cleavages)
Activity statushuman: active (Arlaud et al., 2004)
mouse: active (Arlaud et al., 2002)
PhysiologyActivates component C1s in complement activiation.
Pathways KEGGComplement and coagulation cascades
KEGGPertussis
KEGGStaphylococcus aureus infection
KEGGSystemic lupus erythematosus
Other databases TREEFAMhttp://www.treefam.org/family/TF330373
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
C1R 12p13 ENSG00000159403 715 C1R 216950