Summary for peptidase S01.193: complement component activated C1s

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Substrates Inhibitors Pharma


MEROPS Namecomplement component activated C1s
Other namescalcium-dependent serine proteinase, C1 esterase
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.193
Holotypecomplement component activated C1s (Homo sapiens), Uniprot accession P09871 (peptidase unit: 438-682), MERNUM MER0000239
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00301
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase
EnzymologyBRENDA database
Proteolytic eventsCutDB database (3 cleavages)
Activity statushuman: active (Arlaud, 2004)
mouse: active (by similarity)
InhibitorsNot trapped by alpha-2-macroglobulin (Barrett 1981).
PhysiologyContributes to classical pathway of activation of complement as component of C1, by cleavage of C4 and C2.
Pathways KEGGComplement and coagulation cascades
KEGGStaphylococcus aureus infection
KEGGSystemic lupus erythematosus
Other databases TREEFAM
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
C1S 12p13 ENSG00000182326 716 C1S 120580