Summary for peptidase S01.196: complement factor Bb

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namecomplement factor Bb
Other namesactivated factor B of alternative-complement-pathway C3/C5 convertase
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.196
Holotypecomplement factor Bb (Homo sapiens), Uniprot accession P00751 (peptidase unit: 440-727), MERNUM MER0000229
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00302
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (2 cleavages)
Activity statushuman: active (Kerr, 2004)
mouse: active (Taylor et al., 1998)
PhysiologyCatalytic component of C3/C5 convertase in classical pathway of complement activation.
KnockoutFactor B-deficient mice have been described (Taylor et al., 1998).
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Complement_factor_B
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CFB 6p21.3 ENSG00000180160 629 BF 138470
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
H2-Bf 17:B1 ENSMUSG00000024371 14962 MGI:105975