Summary for peptidase S01.196: complement factor Bb

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma


MEROPS Namecomplement factor Bb
Other namesactivated factor B of alternative-complement-pathway C3/C5 convertase
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.196
Holotypecomplement factor Bb (Homo sapiens), Uniprot accession P00751 (peptidase unit: 440-727), MERNUM MER0000229
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00302
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (2 cleavages)
Activity statushuman: active (Kerr, 2004)
mouse: active (Taylor et al., 1998)
PhysiologyCatalytic component of C3/C5 convertase in classical pathway of complement activation.
KnockoutFactor B-deficient mice have been described (Taylor et al., 1998).
Other databases WIKIPEDIA
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CFB 6p21.3 ENSG00000180160 629 BF 138470
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
H2-Bf 17:B1 ENSMUSG00000024371 14962 MGI:105975