Summary for peptidase S01.198: mannan-binding lectin-associated serine peptidase 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates


MEROPS Namemannan-binding lectin-associated serine peptidase 1
Other namesmannan-binding lectin-associated serine protease 1, MBP-associated serine protease, P100, Ra-reactive factor, MASP-1
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.198
Holotypemannan-binding lectin-associated serine peptidase 1 (Homo sapiens), Uniprot accession P48740 (peptidase unit: 449-698), MERNUM MER0000244
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00303
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (5 cleavages)
Activity statushuman: active (Schwaeble et al., 2004)
mouse: active (Ogata et al., 1995)
PhysiologyRole in activation of the complement system in innate immunity.
Pathways KEGGComplement and coagulation cascades
KEGGStaphylococcus aureus infection
Other databases TREEFAM
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MASP1 3q27-q28 ENSG00000127241 5648 MASP1 600521
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Masp1 16:B2-B3 ENSMUSG00000022887 17174 MGI:88492