Summary for peptidase S01.198: mannan-binding lectin-associated serine peptidase 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates

 

Names
MEROPS Namemannan-binding lectin-associated serine peptidase 1
Other namesmannan-binding lectin-associated serine protease 1, MBP-associated serine protease, P100, Ra-reactive factor, MASP-1
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.198
Holotypemannan-binding lectin-associated serine peptidase 1 (Homo sapiens), Uniprot accession P48740 (peptidase unit: 449-698), MERNUM MER0000244
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00303
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (5 cleavages)
Activity statushuman: active (Schwaeble et al., 2004)
mouse: active (Ogata et al., 1995)
PhysiologyRole in activation of the complement system in innate immunity.
Pathways KEGGComplement and coagulation cascades
KEGGStaphylococcus aureus infection
Other databases TREEFAMhttp://www.treefam.org/family/TF330373
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MASP1 3q27-q28 ENSG00000127241 5648 MASP1 600521
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Masp1 16:B2-B3 ENSMUSG00000022887 17174 MGI:88492