Summary for peptidase S01.199: complement factor I

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates

 

Names
MEROPS Namecomplement factor I
Other namesC3bINA, complement component C3b inactivator, C3b/C4b inactivator
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.199
Holotypecomplement factor I (Homo sapiens), Uniprot accession P05156 (peptidase unit: 340-576), MERNUM MER0000228
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00304
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.45
EnzymologyBRENDA database
Proteolytic eventsCutDB database (7 cleavages)
Activity statushuman: active (Sim, 2004)
mouse: active (by similarity to human) (Jiang & Molina, 2000)
PhysiologyFactor I has very restricted specificity, cleaving only complement components C3b or C4b in the presence of a cofactor such as factor H (Tsiftsoglou et al., 2005). Rare deficiency in human predisposes to bacterial infection.
Pathways KEGGStaphylococcus aureus infection
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Complement_factor_I
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
CFI 4q24-q25 ENSG00000138799 3426 IF 217030
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Cfi 3:G3 ENSMUSG00000028000 12630 MGI:105937