Summary for peptidase S01.212: plasma kallikrein

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Nameplasma kallikrein
Other namesalpha-kallikrein, beta-kallikrein, Fletcher factor, follipsin (Sus scropha), IRCM-serine protease 1, kallidinogenase, kallikrein 3 [obs.], kallikrein B1, kininogenin, serum kallikrein, KLKB1 g.p. (Homo sapiens) (activated), prekallikrein (activated)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.212
Holotypeplasma kallikrein (Homo sapiens), Uniprot accession P03952 (peptidase unit: 391-628), MERNUM MER0000203
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00306
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.34
EnzymologyBRENDA database
Proteolytic eventsCutDB database (11 cleavages)
Activity statushuman: active (Colman, 2004)
mouse: active (Seidah et al., 1990)
PhysiologyLiberates bradykinin from kininogen. Also plays other roles in blood coagulation and inflammation. Thought to contribute to maturation of the ovarian follicle and ovulation.
Pathways KEGGComplement and coagulation cascades
Other databases TREEFAMhttp://www.treefam.org/family/TF343687
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/k/RKScissile bond-/-/g/gfl (based on 40 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 4 3 1 0 1 7 13 9
Pro 1 4 1 0 0 4 2 0
Ala 0 1 1 0 2 0 0 0
Val 3 0 0 0 4 6 0 2
Leu 3 7 2 0 1 0 1 6
Ile 0 0 0 0 1 2 0 1
Met 1 3 3 0 1 1 0 0
Phe 2 3 6 0 0 2 2 6
Tyr 4 1 0 0 7 3 3 1
Trp 0 0 2 0 0 0 0 2
Ser 8 1 0 0 5 1 1 2
Thr 2 1 5 0 2 0 0 0
Cys 1 0 0 0 0 0 0 0
Asn 0 0 0 0 1 1 1 0
Gln 0 3 3 0 0 1 3 0
Asp 2 2 0 0 0 1 2 0
Glu 1 2 1 0 0 1 1 1
Lys 1 1 9 11 2 0 1 0
Arg 0 3 1 29 6 1 1 2
His 0 1 2 0 1 1 1 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
KLKB1 4q35 ENSG00000164344 3818 KLKB1 229000
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Klk3 8:B1.1 ENSMUSG00000031640 16621 MGI:102849