Summary for peptidase S01.213: coagulation factor XIa

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namecoagulation factor XIa
Other namesF11 g.p. (Homo sapiens) (activated), HEMOLEVEN, plasma thromboplastin antecedent
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.213
Holotypecoagulation factor XIa (Homo sapiens), Uniprot accession P03951 (peptidase unit: 388-625), MERNUM MER0000210
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00307
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.27
EnzymologyBRENDA database
Proteolytic eventsCutDB database (7 cleavages)
Activity statushuman: active (Walsh, 2004)
mouse: active (Gailani et al., 1997)
PhysiologyActivates factor IX in contact phase of blood coagulation.
Pathways KEGGComplement and coagulation cascades
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Coagulation_factor_Xia
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage patternkd/fl/t/RScissile bondva/ve/gt/gv (based on 12 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 0 0 4 5
Pro 0 0 2 0 0 0 0 0
Ala 1 0 1 0 3 0 1 0
Val 0 0 0 0 4 5 0 2
Leu 0 4 1 0 0 0 0 0
Ile 1 0 0 0 1 1 0 1
Met 0 0 0 0 0 0 0 0
Phe 0 4 0 0 0 0 1 0
Tyr 0 0 0 0 0 0 0 0
Trp 0 0 1 0 0 0 0 1
Ser 0 0 1 0 0 0 0 1
Thr 0 0 5 0 1 0 3 0
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 0 0 1 0
Gln 0 1 0 0 0 0 0 0
Asp 3 0 0 0 0 1 0 0
Glu 1 1 0 0 0 3 0 0
Lys 4 1 0 1 0 0 0 0
Arg 0 0 0 11 0 0 0 0
His 0 0 1 0 1 0 0 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
F11 4q35 ENSG00000088926 2160 F11 264900
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
F11 8:B1.1 ENSMUSG00000031645 72031 MGI:1919281