Summary for peptidase S01.218: protein C (activated)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Nameprotein C (activated)
Other namesactivated protein C, APC, protein Ca, PROC g.p. (Homo sapiens) (activated)
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.218
Holotypeprotein C (activated) (Homo sapiens), Uniprot accession P04070 (peptidase unit: 212-452), MERNUM MER0000222
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00312
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.69
EnzymologyBRENDA database
Proteolytic eventsCutDB database (9 cleavages)
Activity statushuman: active (Shen & Dahlback, 2004)
mouse: active (by similarity) (Tada et al., 1992)
PhysiologyHuman activated protein C (APC) is an antithrombotic, antiinflammatory serine protease. It proteolytically destroys active coagulation factors Va and VIIIa, thus interfering in thrombin activation.
KnockoutHuman mutations lead to hyper-coagulability disorders (Lind et al., 2002). See also OMIM.
Pharmaceutical relevanceSuccess in altering the substrate specificity and in vivo activity of activated protein C by mutagenesis suggests that there may be therapeutic opportunities for the use of protein C derivatives in disease states with elevated serine protease inhibitor levels (Berg et al., 2003). Recombinant activated protein C (as drotrecogin alfa) is distributed for therapeutic use (McLeay, 2004).
Pathways KEGGComplement and coagulation cascades
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Protein_C
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/d/pt/RScissile bondsgm/-/-/- (based on 15 cleavages)
weblogo
Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 0 0 0 0 3 0 0 0
Pro 2 0 4 0 0 1 1 0
Ala 0 1 1 0 0 1 0 0
Val 2 0 0 0 0 1 0 0
Leu 3 1 2 0 0 1 1 2
Ile 1 0 0 0 0 1 0 1
Met 1 0 0 0 3 1 0 0
Phe 0 0 0 0 0 2 1 0
Tyr 0 0 0 0 0 0 0 0
Trp 0 0 0 0 0 0 0 0
Ser 0 1 0 0 4 0 1 0
Thr 0 0 3 0 0 0 0 1
Cys 0 0 0 0 0 0 0 0
Asn 0 0 0 0 1 1 2 2
Gln 0 2 2 0 0 1 3 1
Asp 0 4 0 0 0 0 0 1
Glu 0 2 0 0 0 0 0 1
Lys 2 2 1 1 1 2 2 1
Arg 1 0 1 14 0 0 0 2
His 0 0 0 0 0 0 1 0
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
PROC 2q13-q14 ENSG00000115718 5624 PROC 176860
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Proc 18:B3 ENSMUSG00000024386 19123 MGI:97771