Summary for peptidase S01.223: acrosin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Nameacrosin
Other namesacrosomal proteinase
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.223
Holotypeacrosin (Sus scrofa), Uniprot accession P08001 (peptidase unit: 40-290), MERNUM MER0000079
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00316
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.10
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
Activity statushuman: active (Adham et al., 2004)
mouse: active (Brown, 1983)
PhysiologyPresumed role in fertilization.
KnockoutMice lacking acrosin are fertile, but the Acr(-) sperm have a selective disadvantage when they are in competition with Acr(+) sperm (Adham et al., 1997).
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/Acrosin
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
ACR 22q13-qter ENSG00000100312 49 ACR 102480
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Acr 15:E-F ENSMUSG00000022622 11434 MGI:87884