Summary for peptidase S01.224: hepsin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates Inhibitors Pharma

 

Names
MEROPS Namehepsin
Other namesHPN g.p. (Homo sapiens), TMPRSS1
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.224
Holotypehepsin (Homo sapiens), Uniprot accession P05981 (peptidase unit: 163-407), MERNUM MER0000156
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00317
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (7 cleavages)
Activity statushuman: active (Kurachi & Yamamoto, 2004)
mouse: active (by similarity) (Yu et al., 2000)
PhysiologySuggested to play a role in growth of some cells.
KnockoutMice lacking hepsin are almost normal, and so give little indication of the physiological functions of the enzyme (Wu et al., 1998; Yu et al., 2000).
Pathways KEGGViral carcinogenesis
Other databases WIKIPEDIAhttp://en.wikipedia.org/wiki/HPN_(gene)
Cleavage site specificity Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern-/-/-/RScissile bondkg/-/-/- (based on 110 cleavages)
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Specificity matrix
 
Amino acid P4 P3 P2 P1 P1' P2' P3' P4'
Gly 6 7 6 1 21 10 21 23
Pro 9 2 10 0 0 6 7 4
Ala 3 11 13 1 3 6 10 9
Val 2 6 6 0 15 25 7 4
Leu 5 6 10 2 7 2 11 10
Ile 4 4 4 0 5 8 6 10
Met 3 2 3 0 1 1 1 0
Phe 1 5 2 0 0 5 2 2
Tyr 3 1 3 0 2 1 1 3
Trp 1 0 0 0 1 0 0 0
Ser 10 9 2 0 7 5 13 7
Thr 3 4 7 0 4 4 4 3
Cys 0 1 1 0 2 0 1 0
Asn 3 1 5 0 0 2 2 3
Gln 0 13 11 0 1 15 7 8
Asp 1 0 1 0 0 1 3 5
Glu 1 0 0 0 0 1 1 3
Lys 6 6 8 1 23 7 4 11
Arg 11 7 8 105 11 3 0 0
His 0 0 0 0 3 4 5 1
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
HPN 19q11-q13.2 ENSG00000105707 3249 HPN 142440
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Hpn 7:A3 ENSMUSG00000001249 15451 MGI:1196620