Summary for peptidase S01.229: mannan-binding lectin-associated serine peptidase 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates


MEROPS Namemannan-binding lectin-associated serine peptidase 2
Other namesmannan-binding lectin-associated serine protease 2, MASP-2, MBP-associated serine protease 2, mannose binding lectin-associated serine protease-2
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.229
Holotypemannan-binding lectin-associated serine peptidase 2 (Homo sapiens), Uniprot accession O00187 (peptidase unit: 445-686), MERNUM MER0002758
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00318
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (5 cleavages)
Activity statushuman: active (Schwaeble et al., 2004)
mouse: active (by similarity to human) (Stover et al., 1999)
Pathways KEGGComplement and coagulation cascades
KEGGStaphylococcus aureus infection
Other databases TREEFAM
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MASP2 1p36.3-p36.2 ENSG00000009724 10747 MASP2 605102
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Masp2 4 ENSMUSG00000028979 17175 MGI:1330832