Summary for peptidase S01.229: mannan-binding lectin-associated serine peptidase 2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Human EST Mouse EST Substrates

 

Names
MEROPS Namemannan-binding lectin-associated serine peptidase 2
Other namesmannan-binding lectin-associated serine protease 2, MASP-2, MBP-associated serine protease 2, mannose binding lectin-associated serine protease-2
Domain architecture
MEROPS Classification
Classification Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.229
Holotypemannan-binding lectin-associated serine peptidase 2 (Homo sapiens), Uniprot accession O00187 (peptidase unit: 445-686), MERNUM MER0002758
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Activity
Catalytic typeSerine
PeplistIncluded in the Peplist with identifier PL00318
NC-IUBMBNot yet included in IUBMB recommendations.
Proteolytic eventsCutDB database (5 cleavages)
Activity statushuman: active (Schwaeble et al., 2004)
mouse: active (by similarity to human) (Stover et al., 1999)
Pathways KEGGComplement and coagulation cascades
KEGGStaphylococcus aureus infection
Other databases TREEFAMhttp://www.treefam.org/family/TF330373
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
MASP2 1p36.3-p36.2 ENSG00000009724 10747 MASP2 605102
Mouse genetics
Gene symbol Position Megabases Ensembl Entrez gene MGI
Masp2 4 ENSMUSG00000028979 17175 MGI:1330832